Opportunity Information: Apply for HT942526LRPIA
The DoD Lupus Research Program (LRP) Idea Award (Funding Opportunity Number HT942526LRPIA) is a discretionary grant opportunity run through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), focused on pushing bold, unconventional lupus research ideas that carry higher risk but also the potential for a major payoff. The central goal is to spark innovative work that could lead to a critical discovery or a meaningful leap forward in how lupus is understood, prevented, diagnosed, or treated. In other words, this mechanism is designed for projects where the novelty and potential impact matter more than incremental progress.
A key requirement is that the proposed research must directly address at least one of the FY26 LRP Idea Award focus areas. While the specific focus areas are not listed in the provided text, the program makes clear that alignment with those FY26 priorities is not optional, so applicants need to frame their aims in a way that clearly maps to at least one stated area once they consult the full program announcement. Another important boundary is that clinical trials are not allowed under this award, meaning applicants should plan for non-trial research such as basic, translational, mechanistic, preclinical, computational, biomarker discovery/validation (non-trial), or other innovative approaches that do not meet the definition of a clinical trial.
The announcement highlights several distinctive features intended to lower barriers for fresh ideas. Early-career investigators are explicitly allowed to apply as Principal Investigators, which signals that the program is open to newer independent researchers and not limited to long-established labs. Preliminary data are allowed but not required, which is typical of high-risk/high-reward mechanisms where a concept can be compelling even without extensive prior results. Applicants are also expected to discuss future directions, so proposals should not stop at a single experiment or dataset, but should explain how the work could grow into a broader research trajectory or enable downstream advances relevant to lupus.
There are also limits on how applicants can participate across the broader FY26 LRP portfolio. An individual may only be listed as PI on one application per award mechanism (Idea Award, Impact Award, Transformative Vision Development Award, Transformative Vision Award). Practically, that means a person could submit up to four total PI applications across the FY26 LRP if they apply once to each mechanism, but they cannot submit multiple Idea Awards as PI.
Administratively, the opportunity is categorized under Science and Technology and other Research and Development, with CFDA number 12.420. Eligibility is listed as unrestricted, suggesting a wide range of applicant organizations may be able to apply (for example, academic institutions, nonprofits, or other research entities, depending on the full eligibility rules in the complete notice). The original application closing date is August 24, 2026, and the opportunity was created May 5, 2026. The program anticipates making about five awards. The award ceiling is not provided in the source text, so applicants would need to refer to the full funding announcement for budget caps, performance period, and any cost constraints.
Overall, this grant is best suited for teams or investigators with a genuinely novel lupus-focused idea that is ambitious, testable, and well-justified, even if it does not yet have extensive preliminary data, and that can be executed without conducting a clinical trial while still pointing toward a plausible path to major impact.Apply for HT942526LRPIA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Lupus, Idea Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2026-05-05.
- Applicants must submit their applications by 2026-08-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted.
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DoD Lupus Research Program (LRP) Idea Award (HT942526LRPIA) - FAQs
1) What is the DoD Lupus Research Program (LRP) Idea Award?
The LRP Idea Award is a discretionary research funding opportunity managed through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to support bold, unconventional lupus research concepts that may be higher risk but have the potential for a major scientific or clinical payoff. The emphasis is on innovation and potential impact rather than incremental progress.
2) What is the main goal of this award?
The central goal is to spark innovative lupus research that could lead to a critical discovery or a meaningful leap forward in how lupus is understood, prevented, diagnosed, or treated. Proposals should clearly communicate why the idea is novel and how it could unlock major advances if successful.
3) What is the Funding Opportunity Number for this grant?
The Funding Opportunity Number is HT942526LRPIA.
4) Who runs or administers this funding opportunity?
This opportunity is run through the Department of the Army, specifically the U.S. Army Medical Research Acquisition Activity (USAMRAA), as part of the DoD Lupus Research Program (LRP).
5) What kinds of research does the Idea Award aim to support?
The mechanism targets ambitious, innovative lupus research ideas that may be considered high-risk/high-reward. The provided description suggests non-clinical-trial research approaches could include basic research, translational or mechanistic studies, preclinical work, computational approaches, and biomarker discovery/validation (as long as the work does not meet the definition of a clinical trial).
6) Are clinical trials allowed under this award?
No. Clinical trials are not allowed under the LRP Idea Award. Applicants should design projects that do not meet the definition of a clinical trial.
7) If clinical trials are not allowed, what types of studies are still possible?
Based on the information provided, allowable directions may include basic, translational, mechanistic, preclinical, computational, and biomarker discovery/validation work, as long as the project is not a clinical trial. Applicants should ensure their planned activities fit within non-trial research boundaries.
8) Do applicants need to address specific program priorities or focus areas?
Yes. A key requirement is that the proposed research must directly address at least one of the FY26 LRP Idea Award focus areas. Alignment with those FY26 priorities is not optional.
9) Are the FY26 LRP Idea Award focus areas listed here?
No. The specific FY26 focus areas are not included in the text provided. Applicants will need to consult the full program announcement to identify the focus areas and explicitly map their aims to at least one of them.
10) Is preliminary data required to apply?
No. Preliminary data are allowed but not required. This reflects the high-risk/high-reward intent of the mechanism, where a compelling concept may be competitive even without extensive prior results.
11) Can early-career investigators serve as Principal Investigators (PIs)?
Yes. Early-career investigators are explicitly allowed to apply as PIs. The program is not limited to only long-established labs and is intended to lower barriers to proposing fresh ideas.
12) What is expected regarding future directions in the proposal?
Applicants are expected to discuss future directions. Proposals should go beyond a single experiment or dataset and explain how the work could grow into a broader research trajectory or enable downstream advances relevant to lupus.
13) How many awards does the program expect to make?
The program anticipates making about five awards.
14) What is the application closing date?
The original application closing date is August 24, 2026.
15) When was this opportunity created?
The opportunity was created May 5, 2026.
16) Is there a limit to how many applications someone can submit as PI?
Yes. An individual may only be listed as PI on one application per award mechanism across the FY26 LRP portfolio (Idea Award, Impact Award, Transformative Vision Development Award, Transformative Vision Award). This means a person cannot submit multiple Idea Award applications as PI.
17) Could someone submit as PI to more than one FY26 LRP mechanism?
Yes. As described, a person could submit up to four total PI applications across FY26 LRP if they apply once to each mechanism (Idea Award, Impact Award, Transformative Vision Development Award, Transformative Vision Award), but only one per mechanism.
18) What is the CFDA number for this opportunity?
The CFDA number listed is 12.420.
19) How is the opportunity categorized?
It is categorized under Science and Technology and other Research and Development.
20) Who is eligible to apply?
Eligibility is listed as unrestricted. The text suggests a wide range of applicant organizations may be able to apply (for example, academic institutions, nonprofits, or other research entities), though full eligibility conditions would be confirmed in the complete notice.
21) Is there an award ceiling or budget cap listed here?
No. The award ceiling is not provided in the source text. Applicants would need to refer to the full funding announcement for budget caps, performance period, and any cost constraints.
22) What types of projects are the best fit for this mechanism?
This award is best suited for investigators or teams with a genuinely novel, ambitious, and testable lupus-focused idea that is well-justified, does not require conducting a clinical trial, and has a plausible path toward major impact even if preliminary data are limited.
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| DoW Lupus, Transformative Vision Development Award Apply for HT942526LRPTVDA Funding Number: HT942526LRPTVDA Agency: Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoW Lupus, Impact Award Apply for HT942526LRPIPA Funding Number: HT942526LRPIPA Agency: Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoW Lung Cancer Patient-Centered Outcomes and Survivorship Award Apply for HT942526LCRPPCOSA Funding Number: HT942526LCRPPCOSA Agency: Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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