Opportunity Information: Apply for RFA HL 20 010
BLOODSAFE: Research to enhance availability of safe blood for patients with severe anemia and hemorrhagic conditions in low or lower-middle income countries (LLMICs) in Sub-Saharan Africa - Data Coordinating Center (DCC) is a National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement opportunity focused on strengthening how safe blood is made available and delivered for transfusion in Sub-Saharan African countries classified as low or lower-middle income. The award supports a single Data Coordinating Center (DCC) that will serve as the operational and analytic hub for the broader BLOODSAFE research consortium. The activity is framed as a U24 cooperative agreement (RFA HL 20 010) with clinical trials not allowed under this specific announcement, meaning the funded DCC is not intended to run an interventional clinical trial itself, but rather to coordinate, standardize, and manage data and cross-site research processes for the program.
The central purpose of the DCC is to ensure that the BLOODSAFE consortium functions like an integrated, multi-site program rather than a set of disconnected projects. In practice, that means the DCC is expected to coordinate consortium activities, support NHLBI oversight of the program, and provide specialized expertise in study design, study management, and analytic methods appropriate for multi-team research operating across different health systems and settings. A major emphasis is placed on building consistent and comparable evidence across projects by developing common measures and shared outcomes, so that findings can be synthesized across participating research teams and translated into practical improvements in blood availability and safe transfusion delivery.
A substantial portion of the DCC role is data-centered. The announcement highlights responsibility for data management and analysis, which typically includes establishing shared data standards, designing data capture and transfer processes, maintaining secure and well-documented databases, and creating clear procedures for data cleaning and version control. The DCC is also charged with ensuring data quality across the consortium, which implies developing quality assurance plans, running routine data checks, monitoring completeness and consistency, and helping sites resolve data issues in a timely way. Because BLOODSAFE is aimed at real-world challenges affecting blood supply and transfusion safety in LLMIC settings, the DCC is expected to help make the resulting data reliable enough to guide decision-making and policy discussions, not just academic reporting.
Beyond technical coordination, the opportunity explicitly stresses collaboration and mutual learning. The DCC is meant to facilitate communication across research teams, support shared problem-solving, and help create a structure where lessons learned in one setting can inform work in another. This can involve organizing consortium meetings and working groups, maintaining shared documentation, supporting harmonized reporting, and helping teams align on definitions, endpoints, and analytic approaches so that outputs are comparable and cumulative. The DCC also assists with program oversight by NHLBI, reflecting the cooperative agreement model where the federal funder remains actively involved in steering and monitoring program progress rather than simply issuing funds and receiving final reports.
From an administrative standpoint, this is a discretionary health funding opportunity offered by the U.S. Department of Health and Human Services (HHS) through NIH. The funding instrument is a cooperative agreement, and the catalog of federal domestic assistance (CFDA) numbers associated with the opportunity are 93.839 and 93.840. The opportunity anticipated a single award (ExpectedAwards: 1), with an award ceiling of $850,000. The original posting date was March 11, 2019, and the original closing date was May 20, 2019.
Eligibility is broad and includes a wide range of U.S.-based organizational types and, as written in the notice, various government entities (state, county, city or township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories), for-profit organizations (other than small businesses), small businesses, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations (as specified). The listing also includes an "Others" category with a note to consult additional eligibility text for clarification, indicating the FOA likely provided further detail on any special conditions or partnership expectations.
Overall, the BLOODSAFE DCC opportunity is designed to fund one coordinating center that can provide the organizational backbone, methodological consistency, and data infrastructure needed for a consortium focused on improving access to safe blood transfusion for patients facing severe anemia and hemorrhagic conditions in Sub-Saharan Africa. The DCC is positioned as the mechanism that enables shared metrics, high-quality multi-site data, and coordinated learning across teams, with NHLBI engaged closely through the cooperative agreement structure.Apply for RFA HL 20 010
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "BLOODSAFE: Research to enhance availability of safe blood for patients with severe anemia and hemorrhagic conditions in low or lower-middle income countries (LLMICs) in Sub-Saharan Africa - Data Coordinating Center (DCC) (U24 Clinical Trial Not Allow" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839, 93.840.
- This funding opportunity was created on Mar 11, 2019.
- Applicants must submit their applications by May 20, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $850,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs): BLOODSAFE Data Coordinating Center (DCC) Opportunity
1) What is the BLOODSAFE DCC funding opportunity?
BLOODSAFE: Research to enhance availability of safe blood for patients with severe anemia and hemorrhagic conditions in low or lower-middle income countries (LLMICs) in Sub-Saharan Africa - Data Coordinating Center (DCC) is an NIH/NHLBI cooperative agreement opportunity to support a single Data Coordinating Center that serves as the operational and analytic hub for the BLOODSAFE research consortium.
2) Which federal agency is offering this opportunity?
The opportunity is offered by the U.S. Department of Health and Human Services (HHS) through the National Institutes of Health (NIH), specifically the National Heart, Lung, and Blood Institute (NHLBI).
3) What is the funding mechanism for this award?
The funding mechanism is a cooperative agreement, described as a U24 under RFA HL 20 010.
4) What does the cooperative agreement model mean for this program?
The cooperative agreement model indicates active involvement by the federal funder. In this case, NHLBI is expected to remain engaged in steering and monitoring program progress, rather than only providing funds and receiving final reports.
5) How many awards were expected under this opportunity?
The opportunity anticipated a single award (ExpectedAwards: 1).
6) What is the maximum award amount (award ceiling)?
The award ceiling listed for this opportunity is $850,000.
7) What is the main purpose of the Data Coordinating Center (DCC)?
The DCC is intended to ensure the BLOODSAFE consortium functions as an integrated, multi-site program rather than a collection of disconnected projects. The DCC provides coordination, standardization, and data and cross-site research process management for the overall consortium.
8) Is this DCC expected to run a clinical trial?
No. Clinical trials are not allowed under this specific announcement. The funded DCC is not intended to run an interventional clinical trial itself.
9) If the DCC is not running clinical trials, what work is it expected to do?
The DCC is expected to coordinate consortium activities, support NHLBI oversight, and provide specialized expertise in study design, study management, and analytic methods suitable for multi-team research conducted across different health systems and settings.
10) What geographic and country-income focus does the program emphasize?
The program focus is Sub-Saharan African countries classified as low or lower-middle income (LLMICs).
11) What health problem areas does BLOODSAFE target?
The consortium focus is improving availability of safe blood for transfusion for patients with severe anemia and hemorrhagic conditions.
12) What does the DCC do to support comparability across research projects?
A major emphasis is developing common measures and shared outcomes so evidence is consistent and comparable across projects, allowing findings to be synthesized across participating teams and translated into practical improvements.
13) What data management responsibilities are highlighted for the DCC?
The DCC role includes establishing shared data standards, designing data capture and transfer processes, maintaining secure and well-documented databases, and creating procedures for data cleaning and version control.
14) What data quality responsibilities are included?
The DCC is expected to ensure data quality across the consortium by developing quality assurance plans, running routine data checks, monitoring completeness and consistency, and helping sites resolve data issues in a timely way.
15) Why is data quality and standardization especially important for BLOODSAFE?
The opportunity emphasizes real-world challenges affecting blood supply and transfusion safety in LLMIC settings, so the consortium’s data needs to be reliable enough to inform decision-making and policy discussions, not only academic reporting.
16) What role does the DCC play in collaboration and communication across teams?
The DCC is intended to facilitate communication across research teams, support shared problem-solving, and create a structure where lessons learned in one setting can inform work in another.
17) What operational activities might the DCC lead to keep the consortium aligned?
Examples described include organizing consortium meetings and working groups, maintaining shared documentation, supporting harmonized reporting, and helping teams align on definitions, endpoints, and analytic approaches.
18) What is meant by the DCC serving as an "operational and analytic hub"?
This means the DCC acts as the central backbone for coordinating consortium operations and for managing and analyzing data across sites, supporting consistent methods and integrated outputs across the broader BLOODSAFE program.
19) What are the CFDA numbers associated with this opportunity?
The Catalog of Federal Domestic Assistance (CFDA) numbers listed are 93.839 and 93.840.
20) When was the opportunity originally posted and when did it close?
The original posting date was March 11, 2019, and the original closing date was May 20, 2019.
21) What types of applicants are eligible to apply?
Eligibility is broad and includes (as listed): various U.S. government entities (state, county, city or township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories), for-profit organizations (other than small businesses), small businesses, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations (as specified).
22) What does the "Others" eligibility category mean?
The listing includes an "Others" category with a note to consult additional eligibility text for clarification, indicating there may be further detail in the FOA on special conditions or partnership expectations.
23) What is the overall goal of funding a single DCC for BLOODSAFE?
The intent is to fund one coordinating center capable of providing organizational backbone, methodological consistency, and data infrastructure needed for a consortium focused on improving access to safe blood transfusion in Sub-Saharan Africa, with NHLBI closely engaged through the cooperative agreement structure.
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