Opportunity Information: Apply for PA 17 111
The Neuroscience Research on Drug Abuse (R01) opportunity (Funding Opportunity Number PA 17 111) is a discretionary National Institutes of Health grant designed to support research that explains how abused drugs change the brain over time and how those changes drive substance use disorders. The program is grounded in the idea that repeated drug exposure can reshape brain structure and function in lasting ways, and that despite major scientific advances, there are still key gaps in understanding exactly which neurobiological alterations occur, when they emerge, and how they contribute to dependence, withdrawal, and relapse. Projects proposed under this announcement are expected to focus on the neurobiological mechanisms that underlie substance use disorders, with a particular emphasis on the neuroadaptations linked to chronic use and the transitions between drug taking, abstinence, and renewed use.
A central aim of the FOA is to generate mechanistic knowledge that can eventually translate into better prevention and treatment strategies. In practical terms, the research supported here is meant to identify actionable targets, such as neural circuits, cellular processes, molecular pathways, or biomarkers that help explain vulnerability, progression, and persistence of addiction. The scientific scope is broad: the announcement explicitly welcomes basic research that clarifies fundamental brain mechanisms, translational research that bridges laboratory findings toward human relevance, and clinical research that investigates these processes directly in people. This wide methodological allowance means applicants can propose work ranging from cellular and systems neuroscience to neuroimaging, human laboratory studies, or clinically anchored investigations, as long as the core objective is to understand drug-related neurobiological change and its role in substance use disorders.
The award mechanism is the NIH R01 research project grant, which is commonly used to support substantial, hypothesis-driven projects that can be pursued over multiple years with a defined set of aims. The funding activity category listed is Education and Health, and the CFDA number associated with the program is 93.279. While the source text does not specify an award ceiling or the number of expected awards, the R01 format generally indicates support for well-developed projects with rigorous design, strong feasibility, and clear significance to the mission area.
Eligibility is intentionally expansive and includes many types of organizations that conduct biomedical and behavioral research. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, and eligible federal agencies. Importantly, foreign participation is permitted: non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by NIH policy are allowed, which opens the door to international expertise and study populations when scientifically justified.
Key administrative details provided in the source include an original closing date of 2018-01-24 and a creation date of 2017-01-09. Overall, this FOA is geared toward advancing the neuroscience of addiction by funding rigorous studies that clarify how chronic drug exposure alters the brain and how those alterations influence the cycles of dependence, withdrawal, and relapse, ultimately supporting the long-term goal of improving intervention and treatment options through a stronger mechanistic foundation.Apply for PA 17 111
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Neuroscience Research on Drug Abuse (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2017-01-09.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs) - Neuroscience Research on Drug Abuse (R01) (PA 17 111)
What is the Neuroscience Research on Drug Abuse (R01) opportunity?
This is a discretionary National Institutes of Health (NIH) grant opportunity that supports research aimed at explaining how abused drugs change the brain over time and how those changes contribute to substance use disorders.
What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number is PA 17 111.
What type of award mechanism does this opportunity use?
The program uses the NIH R01 research project grant mechanism, which is typically used for substantial, hypothesis-driven projects with defined aims carried out over multiple years.
What is the main scientific purpose of this FOA?
The main purpose is to generate mechanistic knowledge about how chronic drug exposure reshapes brain structure and function, when these changes emerge, and how they drive key addiction-related outcomes such as dependence, withdrawal, and relapse.
What kinds of research questions does the FOA emphasize?
The FOA emphasizes questions about the neurobiological mechanisms underlying substance use disorders, particularly neuroadaptations linked to chronic drug use and the transitions between drug taking, abstinence, and renewed use.
Why is the program focused on repeated or chronic drug exposure?
The FOA is grounded in the idea that repeated exposure to abused drugs can produce lasting changes in brain structure and function, and that important gaps remain in identifying which neurobiological alterations occur, when they develop, and how they contribute to addiction cycles.
What outcomes or longer-term impacts is the FOA trying to support?
A central aim is to produce knowledge that can eventually translate into improved prevention and treatment strategies by identifying actionable targets relevant to addiction vulnerability, progression, and persistence.
What does the FOA mean by "actionable targets"?
Based on the description provided, actionable targets can include neural circuits, cellular processes, molecular pathways, or biomarkers that help explain risk, disease progression, and the persistence of substance use disorders.
What research approaches are allowed under this announcement?
The scope is broad and explicitly welcomes basic research, translational research, and clinical research, as long as the core objective is understanding drug-related neurobiological change and its role in substance use disorders.
Can projects involve human participants or clinical settings?
Yes. The FOA explicitly welcomes clinical research that investigates these neurobiological processes directly in people, as well as translational work that connects laboratory findings to human relevance.
Does the FOA allow basic neuroscience studies?
Yes. The announcement explicitly welcomes basic research that clarifies fundamental brain mechanisms related to drug abuse and addiction.
What methodologies are mentioned as examples of allowable work?
The description indicates that applicants may propose work ranging from cellular and systems neuroscience to neuroimaging, human laboratory studies, or clinically anchored investigations, as long as the central focus remains on neurobiological changes related to substance use disorders.
Is there a particular focus within substance use disorders research?
Yes. The FOA highlights neuroadaptations tied to chronic use and the transitions between drug taking, abstinence, and renewed use, including how these changes relate to dependence, withdrawal, and relapse.
What is the funding activity category for this opportunity?
The funding activity category listed in the provided information is Education and Health.
What is the CFDA number associated with this program?
The CFDA number provided is 93.279.
Who is eligible to apply?
Eligibility is broad and includes multiple organization types involved in biomedical and behavioral research, including various government entities, educational institutions, nonprofits, and for-profit organizations (other than small businesses), as well as small businesses.
Are U.S. state and local government entities eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Are public and private colleges or universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible to apply?
Yes. Nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also explicitly included.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and Native American tribal organizations that are not federally recognized are also included.
Are school districts eligible applicants?
Yes. Independent school districts are listed among eligible applicants.
Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among additional eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are specifically mentioned as eligible.
Are federal agencies eligible to apply?
Yes. The FOA includes "eligible federal agencies" among the listed eligible applicants.
Is foreign participation allowed?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by NIH policy are allowed.
Can a U.S. organization include a non-U.S. component in the project?
Yes. The provided information states that non-U.S. components of U.S. organizations are eligible and that foreign components (per NIH policy) are allowed.
Does the information provided specify an award ceiling or the number of expected awards?
No. The source text does not specify an award ceiling or the number of expected awards.
What does the FOA suggest about the scale or maturity of projects expected?
Because the mechanism is an NIH R01, the opportunity generally indicates support for well-developed projects with rigorous design, strong feasibility, and clear significance to the program mission area.
What are the key dates provided for this FOA?
The information provided lists a creation date of 2017-01-09 and an original closing date of 2018-01-24.
What is the overall goal of funding research through this FOA?
The overall goal is to advance the neuroscience of addiction by funding rigorous studies that clarify how chronic drug exposure alters the brain and how those alterations influence dependence, withdrawal, and relapse, supporting long-term improvements in interventions and treatments through stronger mechanistic understanding.
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| Neuroscience Research on Drug Abuse (R21) Apply for PA 17 112 Funding Number: PA 17 112 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R21) Apply for PA 17 109 Funding Number: PA 17 109 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Chronic Condition Self-Management in Children and Adolescents (R01) Apply for PA 17 115 Funding Number: PA 17 115 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Core "Center of Excellence" Grant Program (P30) Apply for PAR 17 121 Funding Number: PAR 17 121 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R21) Apply for PA 17 117 Funding Number: PA 17 117 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Health Disparities Among Minority and Underserved Children (R01) Apply for PA 17 118 Funding Number: PA 17 118 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Chronic Condition Self-Management in Children and Adolescents (R21) Apply for PA 17 116 Funding Number: PA 17 116 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R01) Apply for PA 17 110 Funding Number: PA 17 110 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) Apply for PA 17 120 Funding Number: PA 17 120 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Basic Mechanisms of Brain Development Mediating Substance Use and Dependence (R01) Apply for PA 17 119 Funding Number: PA 17 119 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Perception and Cognition Research to Inform Cancer Image Interpretation (R21) Apply for PAR 17 124 Funding Number: PAR 17 124 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Perception and Cognition Research to Inform Cancer Image Interpretation (R01) Apply for PAR 17 125 Funding Number: PAR 17 125 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Quantitative Imaging Tools and Methods for Cancer Therapy Response Assessment (UG3/UH3) Apply for PAR 17 128 Funding Number: PAR 17 128 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Quantitative Imaging Tools and Methods for Cancer Response Assessment (U01) Apply for PAR 17 129 Funding Number: PAR 17 129 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Innovations in Mechanisms and Interventions to Address Mental Health in HIV Prevention and Care Continuum (R21) Apply for PA 17 137 Funding Number: PA 17 137 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovations in Mechanisms and Interventions to Address Mental Health in HIV Prevention and Care Continuum (R01) Apply for PA 17 136 Funding Number: PA 17 136 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NINR Clinical Trial Planning Grant (R34) Apply for PAR 17 133 Funding Number: PAR 17 133 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRCs) (U54) Apply for RFA NS 17 021 Funding Number: RFA NS 17 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,200,000 |
| Activities to Promote Technology Research Collaborations (APTRC) for Cancer Research (Admin Supp) Apply for PA 17 143 Funding Number: PA 17 143 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanisms of Disparities in Chronic Liver Diseases and Cancer (R21) Apply for PAR 17 150 Funding Number: PAR 17 150 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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